They are made soluble by attachment to specifically designed proteins. To calculate non-HDL cholesterol, you only need to know the numbers for total cholesterol and HDL cholesterol (HDL-C).īut, what makes non-HDL cholesterol such a useful measure of future risk? The Role of LipoproteinsĬholesterol and most other lipids are insoluble in blood. However, current evidence suggests that non-HDL cholesterol may be a better tool for risk assessment ( 2). Over the years, LDL cholesterol (LDL-C) has been the most commonly used lipid variable to predict risk ( 1). The value is strongly associated with an increased risk of heart disease. Non-HDL cholesterol (non-HDL-C) is a fraction that can be easily calculated from a traditional lipid panel.
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